Tuesday, July 31, 2012

U.S. Patents Cannabinoids as antioxidants and neuroprotectants

Patent # 6630507

Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH.sub.3, and COCH.sub.3. ##STR1##

Inventors: Hampson; Aidan J. (Irvine, CA), Axelrod; Julius (Rockville, MD), Grimaldi; Maurizio (Bethesda, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Appl. No.: 09/674,028
Filed: February 2, 2001
PCT Filed: April 21, 1999
PCT No.: PCT/US99/08769
PCT Pub. No.: WO99/53917
PCT Pub. Date: October 28, 1999

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KannaLife Sciences signed an exclusive license agreement with The National Institutes of Health – Office of Technology Transfer for the Commercialization of U.S. Patent 6,630,507, "Cannabinoids as Antioxidants and Neuroprotectants".

CP 55,940 is a cannabinoid which mimics the effects of naturally occurring THC was created by Pfizer in 1974. It was never marketed and is currently used to study the endocannabinoid system.  The endocannabinoid system refers to a group of neuromodulatory lipids and their receptors that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis.

Other patents for Cannabinoids

2304669 Isolation of cannabidiolDecember 1942Adams
4876276 (3S-4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinols October 1989Mechoulam et al.
5227537 Method for the production of 6,12-dihydro-6-hydroxy-cannabidiol and the use thereof for the production of trans-delta-9-tetrahydrocannabinol July 1993Stoss et al.
5521215 NMDA-blocking pharmaceuticals May 1996Mechoulam et al.
5538993 Certain tetrahydrocannabinol-7-oic acid derivatives July 1996Mechoulam et al.
5635530 (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them June 1997Mechoulam et al.

6410588 Use of cannabinoids as anti-inflammatory agents June 2002Feldmann et al.

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