Tuesday, July 31, 2012

U.S. Patents Cannabinoids as antioxidants and neuroprotectants

Patent # 6630507

Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH.sub.3, and COCH.sub.3. ##STR1##

Inventors: Hampson; Aidan J. (Irvine, CA), Axelrod; Julius (Rockville, MD), Grimaldi; Maurizio (Bethesda, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Appl. No.: 09/674,028
Filed: February 2, 2001
PCT Filed: April 21, 1999
PCT No.: PCT/US99/08769
PCT Pub. No.: WO99/53917
PCT Pub. Date: October 28, 1999

View patent

KannaLife Sciences signed an exclusive license agreement with The National Institutes of Health – Office of Technology Transfer for the Commercialization of U.S. Patent 6,630,507, "Cannabinoids as Antioxidants and Neuroprotectants".

CP 55,940 is a cannabinoid which mimics the effects of naturally occurring THC was created by Pfizer in 1974. It was never marketed and is currently used to study the endocannabinoid system.  The endocannabinoid system refers to a group of neuromodulatory lipids and their receptors that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis.

Other patents for Cannabinoids

2304669 Isolation of cannabidiolDecember 1942Adams
4876276 (3S-4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinols October 1989Mechoulam et al.
5227537 Method for the production of 6,12-dihydro-6-hydroxy-cannabidiol and the use thereof for the production of trans-delta-9-tetrahydrocannabinol July 1993Stoss et al.
5521215 NMDA-blocking pharmaceuticals May 1996Mechoulam et al.
5538993 Certain tetrahydrocannabinol-7-oic acid derivatives July 1996Mechoulam et al.
5635530 (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them June 1997Mechoulam et al.

6410588 Use of cannabinoids as anti-inflammatory agents June 2002Feldmann et al.

Saturday, July 14, 2012

Psychedelic Salon: A Walk Through Two Great Minds

Timothy Leary and Robert Anton Wilson: A Walk Through Two Great Minds Podcast
(Left) Robert Anton Wilson (Right) Timothy Leary

Download the MP3 

(All of the following quotes are from Timothy Leary)

“I don’t want to legalize drugs. It’s not the government’s business to legalize anything we do privately in our own homes. Are they going to legalize masturbation."

“By far, the number one problem facing our species for the last 25,000 years has been the relentless, ruthless, perennial, almost invisible oppression of women and children by armed men. And it starts in the home.”

“The concept of a generation implies that young people are doing something different.”

“The function of the 21st century is to learn how to operate our brains.”

“The human brain is designed to design realities.”

The way evolution, as I understand it, works is DNA, biological intelligence, Gaia wisdom, egg intelligence does not like final forms. … You’ll see the word ‘adult’ is the past participle of the word ‘grow’. In other words, an adult is someone who has stopped growing, and it is also someone who has reached their final form. And if there is one thing you can say about evolution, she does not like final forms.”

“There really is an awesome epidemic of deliberate stupidity that is laid upon us by the media, by the press, by magazines and so forth. They simply do not raise any of the issues that challenge our interests or intelligence.”

“I have one cause, and that’s the goal of the performing philosopher, is to encourage you, and inspire you, and empower you, to the extent I can, to Think for Yourself and Question Authority.”


The Wise Terence McKenna

“We have to create culture, don't watch TV, don't read magazines, don't even listen to NPR. Create your own roadshow. The nexus of space and time where you are now is the most immediate sector of your universe, and if you're worrying about Michael Jackson or Bill Clinton or somebody else, then you are disempowered, you're giving it all away to icons, icons which are maintained by an electronic media so that you want to dress like X or have lips like Y. This is shit-brained, this kind of thinking. That is all cultural diversion, and what is real is you and your friends and your associations, your highs, your orgasms, your hopes, your plans, your fears. And we are told 'no', we're unimportant, we're peripheral. 'Get a degree, get a job, get a this, get a that.' And then you're a player, you don't want to even play in that game. You want to reclaim your mind and get it out of the hands of the cultural engineers who want to turn you into a half-baked moron consuming all this trash that's being manufactured out of the bones of a dying world.”
― Terence McKenna

Tuesday, July 10, 2012

Currently Reading: Hardcore Zen: Punk Rock, Monster Movies and the Truth About Reality by Brad Warner

Hardcore Zen is not your typical "Zen" book. Brad Warner, the young punk who grew up to be a Zen master, spares no one — just like Reality itself. This bold new approach to the Why of Zen Buddhism is as strongly grounded in the tradition of Zen as it is utterly revolutionary: Warner's voice is hilarious, and he calls on the wisdom of everyone from punk and pop culture icons to the Buddha himself to make sure his points come through loud and clear. The subtitle says it all: there has never been a book like this one.

Favorite Quotes:

"Religions, the supposed institutional repositories of humanity's understanding of the deeper mysteries of the universe, have never offered anything more to me than sophisticated methods of avoiding the truth, of building elaborate fantasies in place of reality".

"The last thing Buddha told his followers before he died was this: "Question Authority"."

"Suffering occurs when your ideas about how things ought to be don't match how they really are".

"........Even if you get what you want it's still suffering because it won't last".

"Nothing can possibly live up to the ideals and fantasies you’ve created. So we suffer because things are not the way we think they ought to be. Rather than face what really is, we prefer to retreat and compare what we’re living through with the way we think it oughta be. Suffering comes from the comparison between the two".

 "Things can never be other than they are. This moment can never be other than it is".

"We have a world in our minds that we call “perfect” and a world in front of us (and within us) that can’t possibly match that image. The problem is the way we let our desires stand in the way of our enjoyment of what we already have".

"The past and the future—even the present—are just inventions by the conscious mind for dealing with reality in an organized way".

"True right and wrong don’t necessarily overlap completely with society’s definitions of right and wrong—and different societies don’t even agree on those definitions in the first place!

"It’s not that a “good person” has only moral thoughts. It’s that they act only upon the moral thoughts and not the immoral ones................Your desires are not what you really are. Not even close. Your thoughts aren’t the real you either. They’re just electrical energy bouncing around in your brain".

"Experiencing anger is like sitting in the bathtub frantically thrashing around and throwing handfuls of water into the air while simultaneously wondering why the hell your head and face keep getting wet. You’re in a stupor so deep you cannot even see that you’re the one causing the problem".

"The universe desires to perceive itself and to think about itself and you are born out of this desire".

"There’s no room for souls or for reincarnation because in order to have a soul, you need to have a past and in order to be reincarnated you need to have a future".


Saturday, July 7, 2012

The "God"damn Particle

Physicists at CERN discovered what they think is the Higgs boson...but that does not prove the existence of God! The Higgs boson is nicknamed the "God Particle" after Leon Lederman's book,
The God Particle: If the Universe Is the Answer, What Is the Question? Lederman actually wanted to name the particle that "goddamn particle" (because It’s been that frustrating to find) but his editor wouldn't let him. Lederman gave this name to the particle because he felt it is "so central to the state of physics today, so crucial to our understanding of the structure of matter, yet so elusive, that I have given it a nickname ..." I like this statement from free thought blogs, "It’s not proof of God, it’s not evidence for an intelligent creator entity, if anything it could help us understand how the fuse on the Big Bang was lit without a God".

P.S. For those of you who don't know what the Higgs boson is..... "the existence of the Higgs boson and the associated Higgs field explain why the other massive elementary particles in the standard model have their mass". And what's are bosons? Bosons are subatomic particles with integer spin and obey Bose–Einstein statistics. And for Hadron's...These particles are combinations of quarks. They have mass and reside in the nucleus. The two most common examples of hadrons are protons and neutrons.
Large Hadron Collider

The Higgs boson particle was found using the Large Hadron Collider (the world's most powerful atom smasher) at CERN, which smashes beams of protons together.

A recent poll from the Guardian showed that 83% of people think that now that scientist have discovered the Higgs boson that people should stop referring to it as the "God particle".


Friday, July 6, 2012

Favorite Books

Holographic Universe–Michael Talbot
Cosmic Trigger–Robert Anton Wilson
Be Here Now–Ram Dass
Global Brain–Howard Bloom
The Power of Now–Eckhart Tolle
The Tibetan Book of the Dead
You Are Not the Target–Laura Huxley
Between Heaven and Earth–Laura Huxley
Wholeness and the Implicate Order–David Bohm

Thursday, July 5, 2012

Currently Reading: Holotropic Breathwork by Stan and Christina Grof

Stanislav Grof and Christina Grof describe their groundbreaking new form of self-exploration and psychotherapy: Holotropic Breathwork. Induced by very simple means, the breathwork utilizes the remarkable healing and transformative potential of nonordinary states of consciousness and integrates the insights from modern consciousness research, depth psychology, transpersonal psychology, anthropology. Eastern spiritual practices, and mystical traditions. Written in a clear, easily understandable style, this indispensable book summarizes the Grofs' remarkable insights.

Link to Google Books

Favorite quotes: